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The rd1 mouse is a common animal model used to study RP in which the expression of over 60 genes, related to proliferation, apoptosis, and transcription, is modified via a mutation in the phosphodiesterase-6 gene, which affects the metabolism of cyclic guanosine monophosphate

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This indicated that SLC15A4 is a novel link between inflammasome activation and phagocytosis by coupling phagosomal content sensing to mTORC1 signaling (142)